Neuropsychiatric disorders are frequently associated with metabolic comorbidities, including obesity, dyslipidemia, impaired glucose regulation, and hypertension. Similarly, metabolic syndromes increase the risk of developing mental health conditions. The complex interplay of these factors demands an integrative approach spanning nutrition, exercise science, endocrinology, immunology, psychiatry, and neurology, supported by robust basic and clinical neuroscience. It examines how disorders of cellular metabolic processes, particularly those that affect the brain, can result in major psychiatric syndromes and the over-representation of some neurometabolic disorders in psychiatric illness